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Tranilast, an
antioxidant and a
derivative of the amino acid tryptophan, is
an anti-allergic agent that
seems to relieve
many conditions caused by inflammation.
Users report that it eliminates discomfort
within minutes if it’s applied immediately
after injury or at the onset of symptoms. We
have found that it has a wide margin of
safety and negligible toxicity, so it seems
that tranilast can be used as needed to
treat a wide variety of conditions
such as hives, bronchial asthma, nasal
congestion, scars, keloids, and skin
contractures. In topical form, it
can also
provide welcome relief from minor
afflictions like the pain of superficial
burns, the itching of aggressive hives, and
the discomfort of seasonal nasal congestion.
The following reports describe the use of
tranilast to treat 3 common but
uncomfortable afflictions.
Tranilast
for Hives One of my clients, a 64-year-old woman
in good health, noticed itching and redness
on one shin several hours after she had
eaten fresh
strawberries. Hives developed overnight on
that shin. Although she was treated with
loratadine (Claritin) once daily for 5 days,
the hives continued to spread in an area
that increased in
size each subsequent day and itched
severely. The itching intensified at night,
and soon even the gentle touch of clothing
and bathing or showering with warm water had
become painful. Five days after the initial
outbreak of hives, the entire front of the
afflicted leg was covered in lesions that
produced itching of increasing intensity.
On the fifth day of the outbreak,
topical
tranilast 10% in
a simple vanishing cream base was
applied twice daily and was rubbed into the
hive-covered area. Within 24 hours
of the
first application of tranilast, the hives
had faded and the intense itching had begun
to resolve.
Topical tranilast was applied twice daily as
described for 9 additionaldays, by
which time the hives had completely
disappeared. It’s possible that the symptoms
described would have resolved within that
period of time without the use of tranilast,
but improvement occurred very shortly after
the first application of the tranilast-containing
cream, so we attribute the improvement to
tranilast. No adverse effect of
treatment was noted, and the
client
described topical
tranilast as “a blessed solution” to
her skin problem.
Tranilast
for Nasal Congestion An 18-year-old client prefers a
topical
treatment for her seasonal nasal congestion,
which she usually experiences during the
spring and autumn. She applies a pea-size
amount of topical
tranilast
10% in a vanishing cream base to the
outside of each nostril
and around the
sinuses to prevent a stuffy nose. She
applies the tranilast once in morning and
once at night for 2-week periods and
as
needed. Her nasal congestion resolves a few
minutes after the application of the
topical
tranilast, and relief persists for about 3
hours. She’s experienced no adverse
treatment-related effects, and she continues
to find topical
tranilast extremely effective in
preventing and relieving her nasal
congestion.
Tranilast DuringAir Travel
After having heard that tranilast helps
prevent and relieve ear and sinus problems
during airline travel, I tried a topical
form during a recent flight. I rubbed a
small amount of the cream over my sinuses
and behind my ears and was pleased to find
that it really worked; no nasal congestion
developed,and my
ears didn’t pop or get clogged as they
usually do during a flight.
We began to look
into why tranilast seems to be so effective
and found that it inhibits the release of
substances such as histamine and
prostaglandins, which often cause the
symptoms of allergy (inflammation, swelling,
itching). Further investigation revealed
that topical tranilast has demonstrated
effectiveness in treating scars, keloids,
and other skin disorders. In one study, a
14-year-old boy with localized scleroderma
(a chronic disorder that involves the
hardening and thickening of the skin)
experienced what the authors termed “a
dramatic improvement in contractures” after
treatment with tranilast.
I discovered
another use for
tranilast when I sustained a
second-degree burn to
the back of my
hand after inadvertently touching the side
of my furnace chimney during winter. I
applied tranilast 10% cream to the burned
area right away and noticed the immediate
relief of pain and redness. Healing was
evident a few days later, and 6 days after
the burn, I had no sign of injury.
We have found
that topical tranilast (as opposed to oral
dosage forms) provides fairly good and
prompt relief when applied as needed. We
usually recommend applying a 10% topical
tranilast cream in an amount that would fit
on a fingertip and reapplying the cream as
needed. We are not aware of any particular
upper limit to the number of times that
tranilast can applied in a day, but from our
limited experience, it seems safe to use in
almost any amount.
Adapted with
permission from the International
Journal of Pharmaceutical Compounding.
September 2007.
Tranilast
10% TD 8ml Syringe $9.00 Click
HERE to Order
Tranilast 10% TD 30ml Frosted Pumper (0.25ml
dose) $29.00 Click
HERE to Order
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