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L-TRYPTOPHAN RETURNS
L-Tryptophan and 5-HTP - How to decide which is right for you. 

Usage Information

Some people are helped by 5-HTP, others are not.  There are several reasons for these differences that can help in deciding which is right for you.

  1. The body remains in control with L-Tryptophan, but does not with 5HTP.  The creation of neurotransmitter serotonin begins with L-Tryptophan which converts to 5HTP, which converts to serotonin.  The rate-limiting step (the step the body uses to regulate serotonin production) is between L-Tryptophan and 5HTP.  If you take 5HTP your body looses control of the serotonin pathway.

  2. 5HTP converts to serotonin outside the brain.  Since the conversion of 5HTP to serotonin is not regulated some of the 5HTP converts to serotonin in the gut, causing upset and nausea.  Since serotonin does not cross the blood-brain barrier, serotonin produced outside the brain is not available to the brain.  In Europe, 5HTP is combined with carbidopa, a pharmaceutical drug that reduces conversion of 5HTP to serotonin outside the brain.  This is rarely done in the U.S.

  3. Disease impairs 5HTP transport across the blood-brain barrier.  In people with certain diseases, including severe depression, there is blockage of the transmission of 5HTP across the blood-brain barrier.  In these patients supplementation with L-Tryptophan, which does cross the blood-brain barrier, can provide increased brain serotonin levels.

  4. Unlike 5HTP L-Tryptophan has many other uses in the body.  It can be converted to niacin.  It is a required precursor to the kynurenines, a family of biochemicals that help regulate the immune system.  As an essential amino acid, L-Tryptophan is required for your body to work properly.

Even though L-Tryptophan and 5HTP are metabolized to serotonin along the same biochemical pathway, individual differences in metabolism can cause significant differences in effectiveness.

 

L-Tryptophan

5HTP

 Body regulates conversion to serotonin

 Conversion is unregulated

 Body controls WHERE conversion occurs

 Partially converts to serotonin in the gut and blood, not the brain

 Cross the blood-brain barrier in sickness and health

 Disease blocks the absorption process

 L-Tryptophan is an essential amino acid

 5HTP is not essential

 Utilized in many body functions

 Can convert to serotonin  only

 

The above information was provided by Craig Nutraceuticals, Inc., the supplier of a very high quality L-Tryptophan supplement.  We have chosen Craig Nutraceuticals, Inc. as our supplier for L-Tryptophan capsules. 

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L-Tryptophan IS available without a prescription (effective March, 2004).  And you can purchase it from us.  We have found a supplier that offers the highest quality L-Tryptophan available.  The price is the same as before.  I have the assurance of the company that the product is in full supply and they do not expect any interruptions in service

REFERENCES

Pharmacokinetic Factors in the Clinical Use of Tryptophan, J. Clinical Psychopharmacology, 1984
Broadhurst, “Tryptophan for Rheumatic Diseases”
Farkes, Dunner, Fieve, “L-Tryptophan in Depression”’ Biological Psychiatry, 1976.
Seltzer, S. “Pain Relief by Dietary Manipulation and Tryptophan Supplements”. J. of End, 1985
Hoyes, S. “Experiences with L-Tryptophan in a child and Family Psychiatric Dept.”, J. Med. Research, 1982
Hoshino, Yamamato et al., “Blood Serotonin and Free Tryptophan Concentration in Autistic children”, Neuropshychiatry, 1984
Balch, J. MD., Balch P., CNC, Prescription for Nutritional Healing, 1997
Spinweber et al, Navel Health & Res. Cent, “Jet Lag in Mil. Oper.: Field Trial of L– Trypt. In Red. Sleep=Loss Effects, Report #86-15,1986.
Greenfield, Stembach (ed) Handbook of Psychophysiology, 1972
Tryptophan in the Treatment of Depression and Mania”, Adv. Biol. Psychiatry, 1983.
“Depression and Serotonin Metab.: Rational for Neurotransmitter Precursor Treat.” J. Clin Psychopharmacology., 1985
Boushey, Warnock, U. of S.F. Med. School, “Neurologic Aspects of Cocaine Abuse”, West J. Med., 1988.