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SPLENDA CAN KILL YOU

Splenda, also known as sucralose, is artificial sweetener which is a chlorinated sucrose derivative.
Facts about this artificial chemical follows:

Pre-Approval Research
Pre-approval research showed that sucralose caused shrunken thymus glands (up to 40% shrinkage) and enlarged liver and kidneys. The manufacturer put forth two arguments in an attempt to claim that sucralose is not toxic:

The dose of sucralose in the experiments was high. However, for chemicals that do not have generations of safe use, the dosage tested must be adjusted for variations in potential toxicity within the human population and between humans and rodents. In order to this, toxicologists estimate a variation of effects in the human population of 10 times. In other words, one person may not have effects until a dose of 10 mg per kg of body weight (10 mg/kg) is reached, while another person may have chronic toxicity effects at 1 mg per kg of body weight (1 mg/kg). In addition, it is well known that many chemicals are much more toxic in humans than in rodents (or even monkeys). For example, the chemicals that the sweetener aspartame breaks down into vary from 5 to 50 times more toxic in humans than in rodents. Therefore, toxicologists estimate a further 10 times the dose for differences between human and rodent toxicity for a total of 100 times (10 * 10).

In order to estimate a potential safe dose in humans, one must divide the lowest dose in given to rodents that was seen to have any negative effects on their thymus glands, liver or kidneys by 100. That dose is then known as the maximum Tolerable Daily Intake (TDI) for lifetime use. Keep in mind that the TDI is just an estimate. Some chemicals are much more than 10 times more toxic in humans than in rodents (or will cause cancer in humans in low-dose, long-term exposure and do not cause cancer in rodents at all). A person ingesting the TDI for some chemical may find that it causes cancer or immune system or neurological problems after many years or decades of use. So, if the manufacturer claims that the dose was equivalent to 50 diet sodas, then the TDI would be one half (1/2) of a diet soda, and even that dose may or may not be safe

The manufacturer claimed that the sucralose was unpleasant for the rodents to eat in large doses. They said that starvation caused the shrunken thymus glands. From the New Scientist (23 Nov 1991, pg 13):

[Toxicologist Judith] Bellin reviewed studies on rats starved under experimental conditions, and concluded that their growth rate could be reduced by as much as a third without the thymus losing a significant amount of weight (less than 7 percent). The changes were much more marked in rats fed on sucralose. While the animals' growth rate was reduced by between 7 and 20 percent, their thymuses shrank by as much as 40 percent.

Recent Research
A possible problem with caecal enlargement and renal mineralization has been seen in post approval animal research.

Sucralose Breaks Down
Despite the manufacturer's mis-statements, sucralose does break down into small amounts of 1,6-dichlorofructose, a chemical that has not been adequately tested in humans.

Independent, Long-Term Human Research
None. Manufacturer's "100's of studies" (some of which show hazards) were clearly inadequate and do not demonstrate safety in long-term use.

Chlorinated Pesticides
The manufacturer claims that the chlorine added to sucralose is similar to the chlorine atom in the salt (NaCl) molecule. That is not the case. Sucralose may be more like ingesting tiny amounts of chlorinated pesticides, but we will never know without long-term, independent human research.

Conclusion
While it is unlikely that sucralose is as toxic as the poisoning people are experiencing from Monsanto's aspartame, it is clear from the hazards seen in pre-approval research and from its chemical structure that years or decades of use may contribute to serious chronic immunological or neurological disorders.