MULTIPLE SCLEROSIS -
NALTREXONE STABILITY IN WATER
Formulation and stability of naltrexone
oral liquid for rapid withdrawal from
methadone
JP Fawcett, NC Morgan, and DJ Woods
OBJECTIVE: To assess the stability
of naltrexone oral liquid prepared from
tablets and powder, ....
DESIGN: Naltrexone 1 mg/mL oral
liquids were prepared from tablets and
powder and stored in the dark at 4, 25,
and 70 degrees C.
SETTING: A university pharmacy
school and affiliated urban teaching
hospital.
CONCLUSIONS: Naltrexone 1 mg/mL oral
liquids prepared from tablets or powder
are stablewhen stored in
the dark for 60 days at 4 degrees C and
for 30 days at 25 degrees C.
The
formulation prepared from tablets
provides flexible dosing in patients
undergoing rapid withdrawal from
methadone.
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