What Is It?:
Glycerin is a neutral, sweet-tasting,
colorless, thick liquid which freezes to a
gummy paste and which has a high boiling
point. Glycerin can be dissolved into water
or alcohol, but not oils. It is highly
"hygroscopic" which means that it absorbs
water from the air. Because of this
hygroscopic quality high concentrated
glycerin can be is dehydrating (absorbs
water). This dehydrating action is
irritating to tissue. When injected into
small veins by a trained professional the
veins can collapse and disappear by being
reabsorbed.
How to
Use: To be used only under the direct
supervision of a physician experienced with
using injectable escharotic substances.
Possible
Side Effects: Irritation and redness at
the site of injection may occur. Allergic
reactions are rare and should not be
disregarded.
Storage:
Store below 25 degrees C – away from direct
sunlight. The in-use period of each
multi-dose prescription is for a single
session of therapy and for the use in the
treatment of a single patient. Unused vial
contents should be discarded immediately
afterwards. Keep in the original
container. Do not use if cloudy or if
particles are observed in the solution.
Comparative Trial Between Sodium Tetradecyl
Sulfate and Glycerin in the Treatment of
Telangiectatic Leg Veins
Dermatologic Surgery.
Volume
29 Page 612 - June 2003.
doi:10.1046/j.1524-4725.2003.29148.xVolume
29 Issue 6 Comparative
Trial between Sodium Tetradecyl Sulfate and
Glycerin in the Treatment of Telangiectatic
Leg Veins Brian C. Leach, MD, and Mitchel P.
Goldman, MD
Background.
Thirteen patients were treated with either
sodium tetradecyl sulfate (STS) or glycerin
to compare the efficacy and adverse sequelae
of each agent.
Objective. To determine the relative
safety and efficacy of two sclerosant
solutions.
Methods.
Each patient's leg veins that were from 0.2
to 0.4 mm in diameter and that did not have
incompetence from the saphenofemoral
junction and whose feeding reticular veins
had been already treated in a prior
sclerotherapy session were randomly treated
with either 0.25% STS or 72% glycerin
solution. Patients were evaluated from 2 to
6 months post sclerotherapy for overall
clinical improvement and incidence of
adverse sequelae.
Results.
Glycerin was comparable to STS in discomfort
of injection but demonstrated a significant
decrease in bruising, swelling, and post
procedural hyperpigmentation. Glycerin also
demonstrated a better, more rapid clearance
of treated telangiectasias.
Conclusions. Seventy-two
percent glycerin is a safe and effective
sclerosant with fewer side effects and more
rapid clearance of telangiectatic leg veins
than
STS.
B. C. LEACH, MD, AND M. P. GOLDMAN, MD HAVE
INDICATED NO SIGNIFICANT INTEREST WITH
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None of the information provided here is to be construed as medical
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